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Latest Articles on Ebola

  • Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L Mon, 16 May 2022 06:00:00 -0400
    Since the outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), public health worldwide has been greatly threatened. The development of an effective treatment for this infection is crucial and urgent but is hampered by the incomplete understanding of the viral infection mechanisms and the lack of specific antiviral agents. We previously reported that teicoplanin, a glycopeptide antibiotic that has been commonly used in the...
  • Pandemic-induced economic policy uncertainty and US stock exchanges Mon, 16 May 2022 06:00:00 -0400
    This study investigates the impacts of pandemic-induced economic policy uncertainties (PIEPU) on the S&P500, Nasdaq-100, and Dow Jones indexes (stock returns). To this aim, for the first time, newly created IDEMV (the Infectious Disease Equity Market Volatility index (henceforth, PIEPU index) is used. The Autoregressive Distributed Lag (ARDL) model and the Toda and Yamamoto (Journal of Econometrics, 1995, 66, pp. 225-250) causality test are applied for the 2009-2020 period. Empirical findings...
  • Investment, Q and epidemic diseases Mon, 16 May 2022 06:00:00 -0400
    We study the effects of epidemic diseases on corporate investment. Epidemic diseases tend to be unanticipated and exogenous to firms' decisions. Using difference-in-difference estimation strategy and a firm-level exposure to an epidemic disease measure, we find that corporate investment declines significantly following the onset of an epidemic disease. We also show that the COVID-19 pandemic has the strongest negative impact on investment when compared to the other most recent epidemic diseases.
  • Mechanisms of phosphatidylserine influence on viral production: a computational model of Ebola virus matrix protein assembly Sat, 14 May 2022 06:00:00 -0400
    Ebola virus (EBOV) infections continue to pose a global public health threat, with high mortality rates and sporadic outbreaks in Central and Western Africa. A quantitative understanding of the key processes driving EBOV assembly and budding could provide valuable insights to inform drug development. Here we use a computational model to evaluate EBOV matrix assembly. Our model focuses on the assembly kinetics of VP40, the matrix protein in EBOV, and its interaction with phosphatidylserine (PS)...
  • Achieving Minimum Standards for Infection Prevention and Control in Sierra Leone: Urgent Need for a Quantum Leap in Progress in the COVID-19 Era! Sat, 14 May 2022 06:00:00 -0400
    CONCLUSION: Although there is encouraging progress in IPC performance, it is slower than desired in light of the COVID-19 pandemic. There is urgent need to mobilize political will, leadership and resources and make a quantum leap forward.
  • Ebola Virus Encodes Two microRNAs in Huh7-Infected Cells Sat, 14 May 2022 06:00:00 -0400
    MicroRNAs (miRNAs) are important gene regulatory molecules involved in a broad range of cellular activities. Although the existence and functions of miRNAs are clearly defined and well established in eukaryotes, this is not always the case for those of viral origin. Indeed, the existence of viral miRNAs is the subject of intense controversy, especially those of RNA viruses. Here, we characterized the miRNA transcriptome of cultured human liver cells infected or not with either of the two Ebola...
  • Topological and Multivalent Effects in Glycofullerene Oligomers as EBOLA Virus Inhibitors Sat, 14 May 2022 06:00:00 -0400
    The synthesis of new biocompatible antiviral materials to fight against the development of multidrug resistance is being widely explored. Due to their unique globular structure and excellent properties, [60]fullerene-based antivirals are very promising bioconjugates. In this work, fullerene derivatives with different topologies and number of glycofullerene units were synthesized by using a SPAAC copper free strategy. This procedure allowed the synthesis of compounds 1-3, containing from 20 to 40...
  • Host Regulation of Ebola Virus Egress and Spread: Role of Cytoskeletal Filamin Proteins Fri, 13 May 2022 06:00:00 -0400
    Ebola virus (EBOV) causes severe hemorrhagic fever associated with high mortality rates in humans. EBOV and other filoviruses are emerging BSL-4 pathogens for which the development of novel and effective therapeutics is urgently needed. Egress and spread of EBOV is mediated by the VP40 matrix protein (eVP40), whereby expression of eVP40 alone directs the production and egress of virus-like particles (VLPs) that accurately mimics the budding process of live infectious virus. We have shown that...
  • The Effects of Point Mutations on the Dimerization Domain of Ebola Virus Protein VP40 Fri, 13 May 2022 06:00:00 -0400
    The Ebola Virus (EBOV) is a deadly virus first identified in 1976 from the Ebola River region of Zaire (presently the Democratic Republic of Congo). EBOV is known for causing viral hemorrhagic fever and it can cause a high mortality rate in infected patients. VP40 is the matrix protein of EBOV (eVP40), which has an N-terminal domain responsible for dimerization and oligomerization of the protein to form filaments of dimers at the plasma membrane inner leaflet of the host cell. The eVP40...
  • High-Performance Computational Molecular Docking for Potential Inhibitors of an Essential Enzyme of Burkholderia pseudomallei Fri, 13 May 2022 06:00:00 -0400
    Melioidosis, caused by the rod-shaped bacteria Burkholderia pseudomallei, is thought to be an understudied and neglected disease. This life-threatening infection, endemic across tropical areas such as northern Australia and southeast Asia, is estimated to kill at least 89,000 people worldwide annually, though this number is thought to be a serious underestimation. The symptoms of this disease are non-specific, resembling other common illnesses, as the bacterium is highly adaptable and able to...