Ebola Virus Net is the web resource for anyone interested in ebola. Ebola (Ebola hemorrhagic fever), is a severe, often fatal disease in humans and nonhuman primates such as monkeys, gorillas, and chimpanzees. Ebola is a rare and deadly disease caused by infection with a virus of the family Filoviridae, genus Ebolavirus. There are five identified Ebolavirus species, four of which have caused disease in humans. Ebola is found in several African countries. The first Ebola species was discovered in 1976 near the Ebola River in the Democratic Republic of the Congo. Since then, outbreaks have appeared sporadically in Africa. The largest outbreak to date was the epidemic in West Africa, which occurred from December 2013, to January 2016, with 28,646 cases and 11,323 deaths. Other outbreaks in Africa began in the Democratic Republic of the Congo in May 2017 and 2018. In July 2019, the World Health Organization declared the Congo Ebola outbreak a world health emergency.
When an infection does occur in humans, the virus can be spread to others through direct contact with the blood or body fluids of a person who is sick with Ebola, or through contact with objects that have been contaminated with the blood or body fluids of an infected person. Until recent, no vaccines were effective. In December 2016, Ebola was found to be 70–100% prevented by rVSV-ZEBOV vaccine, making it the first proven vaccine against the disease. More than 100,000 people have been vaccinated against Ebola as of 2019.
The objectives of Ebola Virus Net are to be the public and professional information resource for ebola and to serve as a network in the exchange of information and news related to ebola.
- Latest deadly Ebola virus outbreak in DR Congo declared over - UN News
Mon, 03 May 2021 15:12 GMT
- Ebola Virus Disease (EVD) - Regional Emergency Health Response Plan 2020-2022 (updated: 27 April 2021) - Democratic Republic of the Congo - ReliefWeb
Tue, 27 Apr 2021 07:00 GMT
- Outbreak Brief 10: Ebola virus disease (EVD) Outbreak – Africa CDC - africacdc.org
Tue, 27 Apr 2021 07:00 GMT
- Spillover or endemic? Reconsidering the origins of Ebola virus disease outbreaks by revisiting local accounts in light of new evidence from Guinea - Guinea - ReliefWeb
Sat, 24 Apr 2021 07:00 GMT
- From Ebola to COVID-19: Advocating for and supplying WASH programs and infrastructure in healthcare facilities - World - ReliefWeb
Mon, 19 Apr 2021 07:00 GMT
- Outbreak Brief 9: Ebola virus disease (EVD) Outbreak – Africa CDC - africacdc.org
Tue, 20 Apr 2021 07:00 GMT
- Ebola Virus Cases Reach 23 in Guinea, Africa Through Early 2021 - Contagionlive.com
Thu, 08 Apr 2021 07:00 GMT
- Ebola Outbreak Over in the Democratic Republic of the Congo – Homeland Security Today - HSToday
Wed, 05 May 2021 23:23 GMT
- An unprecedented genomic analysis helped to curb an Ebola outbreak - Nature.com
Thu, 15 Apr 2021 07:00 GMT
- Democratic Republic of the Congo (DRC) - Ebola Situation Report #40 - April 10, 2021 - Democratic Republic of the Congo - ReliefWeb
Sat, 10 Apr 2021 07:00 GMT
- Lessons for India from the Ebola epidemic - Hindustan Times
Wed, 05 May 2021 12:17 GMT
- As struggle against Covid continues, DR Congo announces end of Ebola outbreak - RFI English
Wed, 05 May 2021 13:42 GMT
- U.S. lifts Ebola-related DRC travel restrictions - Reuters
Sat, 01 May 2021 10:09 GMT
- Three BARDA scientists recognized for Ebola contributions - Homeland Preparedness News
Wed, 05 May 2021 16:17 GMT
- No Ohioans monitored for Ebola after returning from Africa caught virus - The Columbus Dispatch
Tue, 20 Apr 2021 07:00 GMT
- PRO/AH/EDR> Ebola update (34): DR Congo (NK) outbreak end, research
Tue, 04 May 2021 05:34:43 -0400
Ebola -- DR Congo
The Democratic Republic of Congo on Mon 3 May 2021 declared the end of an Ebola outbreak that infected 12 people in the eastern province of North Kivu and killed 6 of them. The outbreak was contained using Merck's (MRK.N) Ebola vaccine, which was given to more than 1600 of the patients' contacts and contacts of contacts, the aid group Medecins Sans Frontieres (MSF), said.
The cases were genetically linked to the 2018-20 Ebola epidemic that killed more than 2200 people, the second highest
- Ebola Thu, 06 May 2021 06:00:00 -0400
- Responding to the 2018-2020 Ebola Virus Outbreak in the Democratic Republic of the Congo: Rethinking Humanitarian Approaches Thu, 06 May 2021 06:00:00 -0400
The Democratic Republic of Congo (DRC) presents a challenging context in which to respond to public health crises. Its 2018-2020 Ebola outbreak was the second largest in history. Lessons were known from the previous West African outbreak. Chief among these was the recognition that local action and involvement are key to establishing effective epidemic-response. It remains unclear whether and how this was achieved in DRC's Ebola response. Additionally, there is a lack of scholarship on how to...
- Engaging religious leaders to promote safe burial practices during the 2014-2016 Ebola virus disease outbreak, Sierra Leone Thu, 06 May 2021 06:00:00 -0400
CONCLUSION: Public health messages promoted by religious leaders may have influenced safe burial behaviours during the Ebola outbreak in Sierra Leone. Engagement of religious leaders in risk communication should be prioritized during health emergencies in similar settings.
- Development of a New Reverse Genetics System for Ebola Virus Thu, 06 May 2021 06:00:00 -0400
Ebola virus (EBOV) is a highly pathogenic negative-stranded RNA virus that has caused several deadly endemics in the past decades. EBOV reverse genetics systems are available for studying live viruses under biosafety level 4 (BSL-4) or subviral particles under BSL-2 conditions. However, these systems all require cotransfection of multiple plasmids expressing viral genome and viral proteins essential for EBOV replication, which is technically challenging and unable to naturally mimic virus...
- The Ferret as a Model for Filovirus Pathogenesis and Countermeasure Evaluation Wed, 05 May 2021 06:00:00 -0400
The domestic ferret (Mustela putorius furo) has long been a popular animal model for evaluating viral pathogenesis and transmission as well as the efficacy of candidate countermeasures. Without question, the ferret has been most widely implemented for modeling respiratory viruses, particularly influenza viruses; however, in recent years, it has gained attention as a novel animal model for characterizing filovirus infections. Although ferrets appear resistant to infection and disease caused by...
- Machine Learning in Discovery of New Antivirals and Optimization of Viral Infections Therapy Wed, 05 May 2021 06:00:00 -0400
Nowadays, computational approaches play an important role in the design of new drug-like compounds and optimization of pharmacotherapeutic treatment of diseases. The emerging growth of viral infections, including those caused by the Human Immunodeficiency Virus (HIV), Ebola virus, recently detected coronavirus, and some others, leads to many newly infected people with a high risk of death or severe complications. A huge amount of chemical, biological, clinical data is at the disposal of the...
- COVID-19 in West Africa: regional resource mobilisation and allocation in the first year of the pandemic Wed, 05 May 2021 06:00:00 -0400
The world continues to battle the ongoing COVID-19 pandemic. Whereas many countries are currently experiencing the second wave of the outbreak; Africa, despite being the last continent to be affected by the virus, has not experienced as much devastation as other continents. For example, West Africa, with a population of 367 million people, had confirmed 412 178 cases of COVID-19 with 5363 deaths as of 14 March 2021; compared with the USA which had recorded almost 30 million cases and 530 000...
- Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial Wed, 05 May 2021 06:00:00 -0400
BACKGROUND: Convalescent plasma has been used for numerous viral diseases including influenza, severe acute respiratory syndrome, Middle East respiratory syndrome and Ebola virus; however, evidence to support its use is weak. SARS-CoV-2 is a novel coronavirus responsible for the 2019 global pandemic of COVID-19 community acquired pneumonia. We have undertaken a randomized controlled trial to assess the efficacy and safety of COVID-19 convalescent plasma (CCP) in patients with SARS-CoV-2...
- Immunological analysis of the murine anti-CD3-induced cytokine release syndrome model and therapeutic efficacy of anti-cytokine antibodies Tue, 04 May 2021 06:00:00 -0400
The aberrant release of inflammatory mediators often referred to as a cytokine storm or cytokine release syndrome (CRS), is a common and sometimes fatal complication in acute infectious diseases including Ebola, dengue, COVID-19 and influenza. Fatal CRS occurrences have also plagued the development of highly promising cancer therapies based on T cell engagers and chimeric antigen receptor (CAR) T cells. CRS is intimately linked with dysregulated and excessive cytokine release including...
- Editorial: mRNA Vaccines and Future Epidemic, Pandemic, and Endemic Zoonotic Virus Infections Tue, 04 May 2021 06:00:00 -0400
There have been rapid developments in safe and effective mRNA vaccines for zoonotic infections in the past year. Years of research have made these advances possible, leading to in vitro-transcribed (IVT) mRNA expressing therapeutic proteins. There are several advantages of mRNA vaccines that include their low-cost manufacturing process, large-scale and rapid production, and the ability to modify the vaccines in response to emerging infections and viral variants. The COVID-19 pandemic and...